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Taking sildenafil in combination with nitrates or nitroglycerin (commonly prescribed for coronary heart problems) may result in a severe drop in blood pressure level that can be likely lethal.

Just like grapefruit, remedies referred to as cytochrome P450 (CP450) inhibitors and substrates can delay how long it requires sildenafil to work and might raise your potential for side effects. CP450 inducers, such as modafinil, reduce the consequences of sildenafil if taken concurrently.

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Sildenafil is in a category of medications identified as PDE5 inhibitors. These medicines prohibit the action 정품비아그라 of phosphodiesterase enzymes, which stop working cyclic guanosine monophosphate.